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CAS RN: 66-32-0 | Product Number: S0093
Strychnine Nitrate
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Purity: >99.0%(T)
Synonyms:
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25G |
$75.00
|
Contact Us | 2 | ≥40 |
|
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| Product Number | S0093 |
| Purity / Analysis Method | >99.0%(T) |
| Molecular Formula / Molecular Weight | C__2__1H__2__2N__2O__2·HNO__3 = 397.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 66-32-0 |
| Reaxys Registry Number | 4919459 |
| PubChem Substance ID | 87575708 |
| Merck Index (14) | 8855 |
| MDL Number | MFCD00078519 |
Specifications
| Appearance | White powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 99.0 % |
| Solubility in hot Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Soluble |
| Solubility (soluble in) | Chloroform |
| Solubility (slightly sol. in) | Ethanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H370 : Causes damage to organs. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P307 + P311 : IF exposed: Call a POISON CENTER or doctor/ physician. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | WL2450000 |
Transport Information:
| UN Number (DOT-AIR) | UN1692 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | I |
| HS Number | 2939.79.0000 |
Application
Strychnine: An Indole Alkaloid with Antagonistic Activity toward Glycine and Acetylcholine Receptors
Strychnine [S0249] is an indole alkaloid obtained from the seeds and bark of Strychnos nux-vomica, has been used as a rodenticide for more than a century. Glycine is an inhibitory transmitter to motor neurons and interneurons in the spinal cord. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors, resulting in disinhibition of motor neurons in the spinal cord.1,2) In addition, strychnine has been a target compound for total synthesis since it was first synthesized by the group of R. B. Woodward in 1954.3,4) Strychnine is poorly soluble in water, but its sulfate [S0094], nitrate [S0093] and hydrochloride [S0257] are moderately soluble in water. (The product is for research purpose only.)
References
- 1) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
- 2) Inhibitory glycine receptors: an update (a review)
- 3) Synthesis of Strychnine (a review)
- 4) Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis
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