CAS RN: 659-18-7 | Product Number: T3010
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|Purity / Analysis Method||>95.0%(T)|
|Molecular Formula / Molecular Weight||C__6H__6BF__9O__3 = 307.91|
|Physical State (20 deg.C)||Liquid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Moisture Sensitive|
|Reaxys Registry Number||1714040|
|PubChem Substance ID||253659909|
|Appearance||Colorless to Almost colorless clear liquid|
|Purity(Neutralization titration)||min. 95.0 %|
|Boiling Point||125 °C|
|Specific Gravity (20/20)||1.44|
A solution of tris(2,2,2-trifluoroethyl) borate (3.0 mmol, 3.0 eq.) in CPME (1 mL) is added dropwise to a mixture of an unprotected amino acid (1.0 mmol, 1.0 eq.) and propylamine (3.0 mmol, 3.0 eq.) in CPME (1 mL) over 1 h at 80 °C or 125 °C. The resulting mixture is stirred for 5 - 15 h. Upon completion, the mixture is diluted with EtOAc or CH2Cl2 (3 mL) and water (0.5 mL). Amberlite IRA-743 and Amberlyst A-26(OH) are added and stirred for 30 min. The mixture is dried over MgSO4 and then filtered. The solids are washed with EtOAc (3 × 20 mL) and the product concentrated in vacuo. The volatile propylamine is removed in vacuo by the addition of CHCl3 to get the clean product.
- Direct amidation of unprotected amino acids using B(OCH2CF3)3
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