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CAS RN: 181934-29-2 | Product Number: T3272
1-[(Trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one
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![1-[(Trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "1-[(Trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one")
Purity: >98.0%(T)
Synonyms:
- TMS-EBX
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$225.00
|
1 | Contact Us | 22 |
|
| 5G |
$675.00
|
1 | 1 | 6 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | T3272 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__2H__1__3IO__2Si = 344.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 181934-29-2 |
| Reaxys Registry Number | 7707098 |
| PubChem Substance ID | 354333836 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(Precipitation Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 140 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2934.99.4400 |
Application
An Ethynylating Agent
Experimental procedure1): A solution of 1 (89 mg, 0.40 mmol, 1.0 eq.) and TMS-EBX (179 mg, 0.520 mmol, 1.3 eq.) in dried THF (6 mL) is stirred at -78 °C for 5 min under nitrogen. After this period of time, TBAF (1 mol/L in THF, 1.3 eq.) is added and mixture is vigorously stirred for 1 h at -78 °C. The reaction mixture is quenched with deactivated silica gel and the solvent is evaporated under reduced pressure. The product is purified by flash chromatography (SiO2, Hexane:EtOAc = 8:1) to afford 2 (92 mg, 0.37 mmol, 93%) as yellow oil.
References
- 1)Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An Exceptional Reagent for the Ethynylation of Keto, Cyano, and Nitro Esters
- 2)A Highly Chemoselective and Practical Alkynylation of Thiols
PubMed Literature
Articles/Brochures
TCIMAIL
[Product Highlights] Useful Hypervalent Iodine Compound for the Introduction of an Ethynyl GroupDocuments (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Analytical Charts
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