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CAS RN: 83105-70-8 | Product Number: U0097
Sultamicillin Tosylate Dihydrate
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Purity: >98.0%(GC)(T)
Synonyms:
- Sultamicillin Tosilate Dihydrate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$91.00
|
2 | Contact Us | 3 |
|
| 1G |
$251.00
|
Contact Us | 1 | 9 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | U0097 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__5H__3__0N__4O__9S__2·C__7H__8O__3S·2H__2O = 802.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 83105-70-8 |
| Related CAS RN | 76497-13-7 |
| Reaxys Registry Number | 25499733 |
| PubChem Substance ID | 354335315 |
| Merck Index (14) | 8992 |
| MDL Number | MFCD01682151 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +168 to +186 deg(C=0.5, water/CH3CN 3:2) |
Properties (reference)
| Specific Rotation | 177° (C=0.5,H2O/HcN=3:2) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol, Methanol |
GHS
Related Laws:
| RTECS# | XH8460000 |
Transport Information:
| HS Number | 2941.10.5000 |
Application
Sultamicillin Tosylate: The Mutual Prodrug of Ampicillin and Sulbactam
Sultamicillin tosylate is a double ester mutual prodrug in which ampicillin [A2092] and the β-lactamase inhibitor sulbactam [S0868] are linked via a methylene group. Sultamicillin is readily absorbed and hydrolyzed by enzymes in the intestinal wall, releasing ampicillin and sulbactam. Ampicillin is an aminopenicillin which exerts its bactericidal activity by inhibiting transpeptidase, an enzyme responsible for the synthesis of the peptidoglycan layer of the bacterial cell wall. Sulbactam is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases, produced by resistant bacteria. Therefore, sultamicillin is effective against a wide range of gram-positive and gram-negative bacteria including Staphylococcus aureus and Staphylococcus epidermidis, including penicillin-resistant and some methicillin-resistant strains. (The product is for research purpose only.)
References
- Sultamicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use
- Role of sultamicillin and ampicillin/sulbactam in the treatment of upper and lower bacterial respiratory tract infections (a review)
- HPLC determination of sulbactam, sultamicillin tosylate, cefaclor, ampicillin and cefoperazone in pharmaceutical preparations
- Quantitative determination of sultamicillin p-toluenesulfonate in pharmaceutical preparations by reversed-phase high-performance liquid chromatography
- HPLC for in-process control in the production of sultamicillin
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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