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CAS RN: 58970-76-6 | Product Number: U0111

Ubenimex


Purity: >98.0%(HPLC)
Synonyms:
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
Documents:
250MG
$136.00
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1G
$402.00
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Product Number U0111
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__2__4N__2O__4 = 308.38 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 58970-76-6
Reaxys Registry Number 4704312
PubChem Substance ID 468593079
Merck Index (14) 9842
MDL Number

MFCD00083262

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 97.0 %
Specific rotation [a]20/D -15.0 to -20.0 deg(C=1, 1mol/L HCl)
Properties (reference)
Melting Point 215 °C(dec.)
Specific Rotation -19° (C=1,1mol/L HCl)
Maximum Absorption Wavelength 268 nm
Solubility (soluble in) Methanol
Solubility (insoluble in) Chloroform, Ethanol, Benzene
GHS
Related Laws:
RTECS# OH2915000
Transport Information:
HS Number 2924.29.7790
Application
Ubenimex: A Competitive and Reversible Protease Inhibitor

Ubenimex (bestatin) is a dipeptide which was originally isolated from a culture filtrate of Streptomyces olivoreticuli. Ubenimex is a competitive and reversible protease inhibitor. It is an inhibitor of leucine aminopeptidase, aminopeptidase B and triamino peptidase, etc, and has been used as an experimental tool in mammals. Ubenimex is also a leukotriene A4 hydrolase (LTA4H) inhibitor, and reportedly suppress tumorigenesis in this animal model.

References


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