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CAS RN: 298-81-7 | Product Number: X0009

Xanthotoxin


Purity: >98.0%(GC)
Synonyms:
  • Methoxsalen
  • 8-Methoxypsoralen
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100MG
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1G
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Product Number X0009
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__1__2H__8O__4 = 216.19 
Physical State (20 deg.C) Solid
CAS RN 298-81-7
Reaxys Registry Number 196453
PubChem Substance ID 87577878
SDBS (AIST Spectral DB) 10625
Merck Index (14) 5988
MDL Number

MFCD00005009

Specifications
Appearance White to Orange to Green powder to crystal
Purity(GC) min. 98.0 %
Melting point 145.0 to 149.0 °C
Properties (reference)
Melting Point 147 °C
Solubility in water Insoluble
Solubility (soluble in) Acetone
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H371 : May cause damage to organs.
H373 : May cause damage to organs through prolonged or repeated exposure.
H341 : Suspected of causing genetic defects.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# LV1400000
Transport Information:
HS Number 2932.20.4500
Application
8-Methoxypsoralen (8-MOP): A Photosensitizer in Combination with UV-A irradiation, called PUVA

5-Methoxypsoralen (5-MOP) [B2840], 8-methoxypsoralen (8-MOP) and 4,5',8-trimethylpsoralen [T2267] are naturally occurring linear psoralens (furocoumarins). They have been successfully used as photosensitizers in combination with UV-A irradiation which is called the psoralen-based PUVA (psoralen + UV-A) to manage dermatological diseases, such as psoriasis, vitiligo and cancer. Reportedly, the most important mechanism implies the [2+2] cycloaddition photoreaction of psoralen and a DNA pyrimidine nucleobase. The formation of psoralen-pyrimidine adducts prevents the division of the injured cells. In another photoreaction, the activated psoralen can transfer energy to molecular oxygen to generate reactive radicals or excited singlet oxygen which becomes prone to damage the membrane of the harmed cell. In addition, 5-MOP and 8-MOP work as Cytochrome P450 inhibitors. (The product is for research purpose only.)

References


PubMed Literature


TCIMAIL
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