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CAS RN: 81938-43-4 | Product Number: Z0041

Zofenopril Calcium


Purity: >97.0%(HPLC)
Synonyms:
  • (4S)-1-[(2S)-3-(Benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline Calcium Salt
Documents:
25MG
$34.00
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100MG
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Product Number Z0041
Purity / Analysis Method >97.0%(HPLC)
Molecular Formula / Molecular Weight C__4__4H__4__4CaN__2O__8S__4 = 897.16 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 81938-43-4
Reaxys Registry Number 6466976
PubChem Substance ID 468593135
Merck Index (14) 10186
MDL Number

MFCD11858294

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 97.0 area%
Properties (reference)
Melting Point 246 °C
GHS
Hazard Statements H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
Related Laws:
Transport Information:
HS Number 2933.99.5300
Application
Zofenopril Calcium: An Angiotensin-Converting Enzyme (ACE) Inhibitor

Zofenopril calcium is an angiotensin-converting enzyme (ACE) inhibitor. Zofenopril is prodrug which is rapidly hydrolyzed to the active metabolite zofenoprilat by hepatic cleavage of the thioester group. It has been reported that zofenopril is characterized by high lipophilicity, selective cardiac ACE inhibition, and antioxidant and tissue protective activities. ACE, a peptidyl dipeptidase, circulates in the plasma and is located on the surface of endothelial cells. ACE is catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Thereby, ACE inhibitors reduce peripheral vascular resistance and blood pressure. For your reference, [B5315] is a key synthetic intermediate of zofenopril. (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
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