Arylboronic Acid

The introduction of a thienyl group often enhances the biological activities as well as their electrical conductivities in certain molecules, and thus a large number of compounds have been experimented. Thiopheneboronic acids 1 are useful reagents for the introduction of this thienyl group to a molecule. As shown in the following examples, the Suzuki-Miyaura coupling reactions of 1 with 5-bromouracil derivatives in the presence of palladium catalyst furnished 5-(2-thienyl) uracil derivatives in a 63% and 73% yield, respectively.^1a)