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CAS RN: 56-75-7 | Product Number: C2255

Chloramphenicol

Purity: >98.0%(T)(HPLC)

Synonyms:

D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide

Product Documents:

Size	Unit Price	Philadelphia, PA	Portland, OR	Japan*	Quantity	Shipping Information
25G	$62.00	19	12	≥80		Shipping Simulation
250G	$275.00	≥40	1	≥60		Shipping Simulation

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* Items in stock locally typically ship the same day of ordering. Items from Japan stock are able to ship from a US warehouse within 2 weeks after ordering. For additional estimated shipment times, please refer to the Shipping Simulation tool. Note: Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Orange to Green powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Argentometric Titration)	min. 98.0 %
Melting point	149.0 to 153.0 °C
Specific rotation [a]20/D	+17.0 to +21.0 deg(C=5, EtOH)

Properties (reference)

Melting Point	151 °C
Specific Rotation	20° (C=5,EtOH)
Solubility (soluble in)	Chloroform, Ether
Solubility (insoluble in)	Benzene

Safety & Regulations plus

GHS

Pictogram
Signal Word	Danger
Hazard Statements	H361 : Suspected of damaging fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. H373 : May cause damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up.

Related Laws:

RTECS#

AB6825000

Transport Information:

HS Number

2941.40.0000

Applications & Literature plus

Application

RNA aptamer research

Reference

RNA aptamers to the peptidyl transferase inhibitor chloramphenicol

D.H. Burke, D.C. Hoffman, A. Brown, M. Hansen, A. Pardi, L. Gold, Chem. Biol. 1997, 4, 833.

Application

Chloramphenicol: A Broad Spectrum Antibiotic and a Selective Reagent Genetically Engineered Cells

Chloramphenicol was originally isolated from the soil bacterium Streptomyces venezuelae in 1947. Chloramphenicol and a congener thiamphenicol [T2802] can now be made by chemical synthesis. Chloramphenicol has a highly stable which can be stored for prolonged times at room temperature. It has a broad spectrum of antibiotic activity including Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli, while it is not effective against Pseudomonas aeruginosa. Chloramphenicol inhibits protein synthesis in susceptible organisms by binding to specific nucleotides in 23S rRNA within the 50S subunit of a bacterial ribosome. However, chloramphenicol causes side effects including bone marrow suppression and aplastic anemia. Chloramphenicol is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for chloramphenicol resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.

References

Chloramphenicol: Relation of Structure to Activity and Toxicity (a review)
- A. A. Yunis, Annu. Rev. Pharmacol. Toxicol. 1988, 28, 83.
Structural basis for the interaction of antibiotics with the peptidyl transferase center in eubacteria
- F. Schlünzen, R. Zarivach, J. Harms, A. Bashan, A. Tocilj, R. Albrecht, A. Yonath, F. Franceschi, Nature 2001, 413, 814.
Molecular basis of bacterial resistance to chloramphenicol and florfenicol (a review)
- S. Schwarz, C. Kehrenberg, B. Doublet, A. Cloeckaert, FEMS Microbiol. Rev. 2004, 28, 519.
High-copy-number and low-copy-number plasmid vectors for lacZ α-complementation and chloramphenicol- or kanamycin-resistance selection
- S. Takeshita, M. Sato, M. Toba, W. Masahashi, T. Hashimoto-Gotoh, Gene 1987, 61, 63.
A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives
- M. Cannon, S. Harford, J. Davies, J. Antimicrob. Chemother. 1990, 26, 307.
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae
- J. A. Thanassi, S. L. Hartman-Neumann, T. J. Dougherty, B. A. Dougherty, M. J. Pucci, Nucleic Acids Res. 2002, 30, 3152.

PubMed Literature

Documents

Antimicrobials and Antitumors for Research and Experimental Use

Pharmaceutical Ingredients for Research and Experimental Use

Product Articles

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Specifications

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Product Number	C2255
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__1__1H__1__2Cl__2N__2O__5 = 323.13
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Condition to Avoid	Light Sensitive
CAS RN	56-75-7
Reaxys Registry Number	2225532
PubChem Substance ID	87560304
Merck Index (14)	2077
MDL Number	MFCD00078159

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CAS RN: 56-75-7 | Product Number: C2255