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CAS RN: 78628-80-5 | Product Number: D2049

Terbinafine Hydrochloride

Chemical Structure of Terbinafine Hydrochloride
×
× Terbinafine Hydrochloride

Purity: >98.0%(T)(HPLC)
Synonyms:
  • trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride
  • (E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine Hydrochloride
Product Documents:
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General Information | Specifications & Properties | Safety & Regulations | Applications & Literature

Explanatory notes for this page

1G
€64.00
 1   ≥100 
5G
€244.00
 1   ≥40 

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

Product Number D2049
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__5N·HCl = 327.90 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 78628-80-5
Related CAS RN 91161-71-6
Reaxys Registry Number 5660449
PubChem Substance ID 87568500
Merck Index (14) 9156
MDL Number

MFCD00145430
Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
NMR confirm to structure
Properties (reference)
Melting Point 214 °C
GHS
Related Laws:
RTECS# QJ8600100
Transport Information:
HS Number 2921490090
Application
Terbinafine Hydrochloride: A Potent Non-Competitive Inhibitor of Squalene Epoxidase

Terbinafine [T3677] and its hydrochloride, allylamine antifungals, are potent non-competitive inhibitors of fungal squalene epoxidase, a key enzyme in ergosterol biosynthesis. Ergosterol is an essential component of fungal cell membrane, and terbinafine inhibits ergosterol synthesis at the stage of squalene epoxidation. This results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiency. (The product is for research purpose only.)

References


PubMed Literature


Documents

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