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CAS RN: 86639-52-3 | Product Number: E0748
7-Ethyl-10-hydroxycamptothecin
×
Purity: >98.0%(HPLC)
Synonyms:
- SN-38
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$140.00
|
35 | ≥40 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$963.00
|
0 | 11 | It can be shipped in about 2 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | E0748 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__0N__2O__5 = 392.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 86639-52-3 |
| Reaxys Registry Number | 4829984 |
| PubChem Substance ID | 87559919 |
| MDL Number | MFCD06762720 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 94.0 % |
| Specific rotation [a]20/D | +20.0 to +30.0 deg(C=0.2, THF) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 217 °C |
| Specific Rotation | 21.5° (C=0.2,THF) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | UQ0491000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.99-000 |
Application
7-Ethyl-10-hydroxy-camptothecin (SN-38): An Active Metabolite of Irinotecan Hydrochloride (CPT-11) with a Topoisomerase-I Inhibitory Activity
7-Ethyl-10-hydroxy-camptothecin (SN-38) is a water insoluble biologically active metabolite of water soluble irinotecan hydrochloride (CPT-11) [I0714]. SN-38 has a topoisomerase-I inhibitory activity and is approximately 100-1000-fold more cytotoxic in vitro than CPT-11. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. Recently, the use of polyethyleneglycolylated nanographene oxide for drug delivery of SN-38 has received widespread attention. (The product is for research purpose only.)
References
- Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
- Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
- Lessons learned from the irinotecan metabolic pathway
- Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile
- PEGylated nanographene oxide for delivery of water-insoluble cancer drugs
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