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CAS RN: 130018-87-0 | Product Number: L0264
Levocetirizine Dihydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic Acid Dihydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
₩87,800
|
≥40 | ≥60 | It can be shipped in about 2 weeks after ordering | |
| 5G |
₩284,700
|
2 | 9 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | L0264 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5ClN__2O__3·2HCl = 461.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 130018-87-0 |
| Related CAS RN
|
130018-77-8 |
| Reaxys Registry Number | 9455577 |
| PubChem Substance ID | 253661576 |
| Merck Index (14) | 2022 |
| MDL Number | MFCD07366507 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 214 °C |
| Degree of solubility in water | 946 g/l |
| Solubility (insoluble in) | Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | AG0990000 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
Levocetirizine Dihydrochloride: A New Histamine H1 Antagonist with a Superior Affinity for H1 Receptors over Its Racemate, Cetirizine [C2316]
Levocetirizine dihydrochloride is a new second-generation histamine H1 antagonist, developed from cetirizine [C2316]. Chemically, levocetirizine is the active R-enantiomer of cetirizine. Levocetirizine has a superior affinity and selectivity for H1 receptors over racemic cetirizine or the S-enantiomer, and has a favorable pharmacokinetic profile.
References
- Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194
- Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1- receptor antagonists
- Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans (a review)
- Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine a comparative review
- Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies
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