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Published TCIMAIL newest issue No.198
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CAS RN: 114798-26-4 | Product Number: L0378
Losartan
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Purity: >98.0%(T)(HPLC)
Synonyms:
- [2-Butyl-4-chloro-1-[[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl]methanol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
61,00 €
|
1 | 8 |
|
| 25G |
202,00 €
|
1 | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0378 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__3ClN__6O = 422.92 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 114798-26-4 |
| Reaxys Registry Number | 4770867 |
| PubChem Substance ID | 468592180 |
| MDL Number | MFCD00865831 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 184 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | NI6732550 |
Transport Information:
| HS Number | 2933299090 |
Application
Losartan: A Reversible, Non-Competitive Antagonist of the AT1 Receptor
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor, and an important component in the pathophysiology of hypertension. Angiotensin II can activate two different receptors, AT1 and AT2. The most important vasoconstrictor action of angiotensin II are mediate trough AT1 receptors. Losartan is a prodrug, and its active metabolite (EXP3174) works as a reversible, non-competitive antagonist of the AT1 receptor. 1-3) In addition, neither losartan nor its active metabolite inhibits ACE nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. In clinical, its water-soluble potassium salt (DUP 753) [L0232] is used for the treatment of hypertension. Recently, AT1 receptor antagonists (blockers), such as losartan, are expected as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections.4) (The product is for research purpose only.)
References
- 1) Angiotensin receptor antagonists: Focus on losartan (a review)
- 2) Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of its efficacy and safety in essential hypertension (a review)
- 3) Clinical pharmacokinetics of losartan (a review)
- 4) Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics (a review)
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