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CAS RN: 50-24-8 | Product Number: P0637
Prednisolone
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Purity: >98.0%(HPLC)
Synonyms:
- 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€34.00
|
5 | 23 | |
| 5G |
€106.00
|
3 | 20 | |
| 25G |
€340.00
|
5 | 15 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P0637 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__8O__5 = 360.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 50-24-8 |
| Reaxys Registry Number | 1354103 |
| PubChem Substance ID | 87574796 |
| SDBS (AIST Spectral DB) | 10998 |
| Merck Index (14) | 7721 |
| MDL Number | MFCD00003649 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +97.0 to +103.0 deg(C=1, Dioxane) |
| Solubility in Dioxane | almost transparency |
Properties (reference)
| Melting Point | 235 °C |
| Specific Rotation | 100° (C=1,Dioxane) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol, Methanol |
| Solubility (slightly sol. in) | Dioxane, Acetone |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 200-021-7 |
| RTECS# | TU4152000 |
Transport Information:
| HS Number | 2937210000 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Prednisolone has been reported to act as a germinant for Clostridium sordellii spores (EC50 = 17.9 μM).4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Progesterone Analogs Influence Germination of Clostridium sordellii and Clostriduim difficile Spores In Vitro
- Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition
- Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids (a review)
- Glucocorticoid action and the development of selective glucocorticoid receptor ligands (a review)
- Allergic and pseudoallergic reactions induced by glucocorticoids: A review
- Simple liquid chromatography method for the rapid simultaneous determination of prednisolone and cortisol in plasma and urine using hydrophilic lipophilic balanced solid phase extraction cartridges
Application
Prednisolone: A Synthetic Adrenocortical Steroid Agent with Predominantly Glucocorticoid Properties
Prednisolone is a synthetic adrenocortical steroid agent with predominantly glucocorticoid properties, which is used for the treatment of a wide range of inflammatory and autoimmune conditions. It is the active hepatic metabolite of prednisone [P1276]. (The product is for research purpose only.)
References
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