Pyridinesulfinates, Pyrimidinesulfinates [Cross-coupling Reaction using Transition Metal Catalysts]

 Pyridine-2-sulfinates and pyrimidine-2-sulfinates can be utilized in Suzuki-Miyaura cross coupling reagents as replacements for pyridine-2-boronic acids and pyrimidine-2-boronic acids, which are difficult to prepare. These reagents are tolerated by ketone, ester, trifluoromethyl, and other functional groups.^1,2) Also the cross-coupling reaction with Grignard reagents proceeds without transition metals.³⁾ It has been reported that these reagents are applied to late-stage modifications in drug discovery, and ligand syntheses for catalytic reactions.