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CAS RN: 163252-36-6 | Product Number: C3845
Clevudine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
- 1-[(2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 250MG |
¥1,180.00
|
4 | Contact Us | 12 |
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| Product Number | C3845 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3FN__2O__5 = 260.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 163252-36-6 |
| Reaxys Registry Number | 8153334 |
| MDL Number | MFCD00935785 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
| Specific rotation | -107 to -117 deg(C=0.2, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 196 °C |
GHS
Related Laws:
| RTECS# | UV9052000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Clevudine: An L-Configuration Thymidine Analog with Antiviral Activity
Clevudine (L-FMAU; 2'-fluoro-5-methyl-β-L-arabinofuranosyluracil) is an unnatural L-configuration thymidine analog with potent anti-hepatitis B virus (HBV) activity in vitro and in vivo. There are reports that clevudine interferes with HBV replication by inhibiting the activity of viral DNA polymerase and reverse transcriptase. (The product is for research purpose only.)
References
- Use of 2'-fluoro-5-methyl-β-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus
- Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent (a review)
- Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication
- Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo (a review)
- Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance (a review)
- Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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