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CAS RN: 244767-67-7 | Product Number: D6168
Dapivirine
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Purity: >97.0%(T)(HPLC)
Synonyms:
- TMC 120
- 4-[(4-(Mesitylamino)pyrimidin-2-yl]amino)benzonitrile
- 4-[[4-[(2,4,6-Trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25MG |
¥410.00
|
4 | Contact Us | ≥40 |
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| Product Number | D6168 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__9N__5 = 329.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 244767-67-7 |
| Reaxys Registry Number | 8934631 |
| MDL Number | MFCD09833899 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 216.0 to 220.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 218 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
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Transport Information:
| Customs Control Conditions (Q) |
Application
Dapivirine: A Potent Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
Dapivirine (TMC 120) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV type 1 (HIV-1) reverse transcriptase (RT), an essential viral enzyme that transcribes viral RNA into DNA. (The product is for research purpose only.)
References
- In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides
- Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide
- Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor
- The development and validation of an UHPLC-MS/MS method for the rapid quantification of the antiretroviral agent dapivirine dapivirine in human plasma
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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