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CAS RN: 24280-93-1 | Product Number: M2216
Mycophenolic Acid
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- (E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥310.00
|
1 | 1 | ≥60 |
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| Product Number | M2216 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__0O__6 = 320.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 24280-93-1 |
| Reaxys Registry Number | 318158 |
| PubChem Substance ID | 135726996 |
| Merck Index (14) | 6327 |
| MDL Number | MFCD00036814 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 141.0 to 145.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 143 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. |
Related Laws:
| RTECS# | MP8050000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Mycophenolic acid (MPA): An Inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH), Needed for the Growth of T Cells and B Cells
Mycophenolic acid (MPA) is an active metabolite of mycophenolate mofetil (MMF) [M2387] with immunosuppressant activity. MPA is a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an important enzyme in the de novo synthesis of guanosine nucleotides in T and B lymphocytes. (The product is for research purpose only.)
References
- Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotdie depletion
- Characterization of human type I and type II IMP dehydrogenases
- Mycophenolic acid binding to human serum albumin: characterization and relation to pharmacodynamics
- Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid
- Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant (a review)
- Validation of a rapid and sensitive liquid chromatography-tandem mass spectrometry method for free and total mycophenolic acid
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