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CAS RN: 60-82-2 | Product Number: P1966
Phloretin
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Purity: >98.0%(HPLC)
Synonyms:
- 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
- 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥210.00
|
16 | 1 | 39 |
| 5G |
¥730.00
|
1 | Contact Us | ≥40 |
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| Product Number | P1966 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__4O__5 = 274.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 60-82-2 |
| Reaxys Registry Number | 1887240 |
| PubChem Substance ID | 135727056 |
| Merck Index (14) | 7326 |
| MDL Number | MFCD00002288 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
Properties (reference)
| Melting Point | 262 °C(dec.) |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| Customs Control Conditions (Q) |
Application
Quorum sensing research / Biofilm research
It has been reported that exposure of phloretin to Pectobacterium brasiliense (Pb1692), an emerging soft-rot pathogen of potato, reduced phenotypes that are associated with quorum sensing (QS), i.e., motility, biofilm formation, secretion of plant cell wall-degrading enzymes, production of acyl–homoserine lactone (AHL) signaling molecules etc.1) In addition, this compound was shown to inhibit biofilm formation of Acinetobacter baumannii.2)
References
- 1) Phloretin, an Apple Phytoalexin, Affects the Virulence and Fitness of Pectobacterium brasiliense by Interfering With Quorum-Sensing
- 2) Antibiofilm and Antivirulence Efficacies of Flavonoids and Curcumin Against Acinetobacter baumannii
- Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
- Effect of phloretin on the permeability of thin lipid membranes
- The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids
- Application of Directly Coupled HPLC-NMR-MS to the Identification and Confirmation of Quercetin Glycosides and Phloretin Glycosides in Apple Peel
Application
Phloretin: A Dihydrochalcone with Many Interesting Biological Properties
Phloretin is a dihydrochalcone and a polyphenol, can be found in apple tree leaves. Phloretin and its glycosylated derivative (phlorizin [P0248]) have many interesting biological properties. For example, phloretin inhibits sodium glucose co-transporters (SGLTs), though the inhibition is weaker than by phlorizin. In addition, phloretin shows an antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation.
References
PubMed Literature
Product Articles
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Specifications
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