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CAS RN: 79559-97-0 | Product Number: S0507
Sertraline Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (1S,4S)-1-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-4-(methylamino)naphthalene Hydrochloride
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥210.00
|
8 | 34 | ≥100 |
| 5G |
¥830.00
|
2 | 3 | ≥100 |
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| Product Number | S0507 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__7Cl__2N·HCl = 342.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 79559-97-0 |
| Related CAS RN
|
79617-96-2 |
| Reaxys Registry Number | 5783715 |
| PubChem Substance ID | 87558859 |
| SDBS (AIST Spectral DB) | 51798 |
| Merck Index (14) | 8467 |
| MDL Number | MFCD00895772 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 245.0 to 249.0 °C |
| Specific rotation [a]20/D | +35.0 to +41.0 deg(C=2,MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 245 °C |
| Specific Rotation | 38° (C=2,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | QJ0352070 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Sertraline Hydrochloride: A Selective Serotonin Reuptake Inhibitor (SSRI)
Sertraline hydrochloride is a selective serotonin (5-hydroxytryptamine; 5-HT [S0370]) reuptake inhibitor (SSRI) that has only very weak effects on norepinephrine [A0906] and dopamine [A0305] neuronal reuptake. in vitro studies have shown that sertraline has no significant affinity for adrenergic (α1, α2, β), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors. In addition, sertraline has minimal inhibitory effects on the major cytochrome P450 enzymes, and few drug-drug interactions of clinical significance have been documented. (The product is for research purpose only.)
References
- Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.
- Review of sertraline and its clinical applications in psychiatric disorders (a review)
- Clinical pharmacokinetics of sertraline (a review)
- Sertraline hydrochloride (a review on preparation, physicochemical properties, methods of detection, stability and pharmacokinetics)
- Simultaneous determination of human plasma levels of citalopram, paroxetine, sertraline, and their metabolites by gas chromatography-mass spectrometry
- High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum
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