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CAS RN: 137862-53-4 | Product Number: V0112
Valsartan
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥30.00
|
2 | 1 | ≥100 |
| 5G |
¥50.00
|
1 | 1 | 30 |
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| Product Number | V0112 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__9N__5O__3 = 435.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 137862-53-4 |
| Reaxys Registry Number | 7754038 |
| PubChem Substance ID | 125307697 |
| SDBS (AIST Spectral DB) | 52923 |
| Merck Index (14) | 9916 |
| MDL Number | MFCD00865840 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -63.0 to -67.0 deg(C=1, methanol) |
Properties (reference)
| Melting Point | 117 °C |
| Specific Rotation | -65° (C=1,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P405 : Store locked up. |
Related Laws:
| RTECS# | YV9455000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Valsartan: A Competitive and Selective AT1 Receptor Antagonist
Valsartan is a competitive and selective AT1 receptor antagonist. Valsartan inhibits the actions of angiotensin II at the AT1 receptor subtype which is responsible for most of the known effects of angiotensin II, a principal pressor agent. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Valsartan blocks the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle. Recently, the combination of valsartan and a thiazide diuretic hydrochlorothiazide [H1274] is often use in clinical. (The product is for research purpose only.)
References
- Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype
- Expression, secretion, and inhibition of angiotensin-converting enzyme in cultured human bronchial epithelial cells
- Valsartan: a review of its pharmacology and therapeutic use in essential hypertension
- Valsartan: more than a decade of experience (a review)
- Valsartan/hydrochlorothiazide. A review of its pharmacology, therapeutic efficacy and place in the management of hypertension
PubMed Literature
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