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CAS RN: 5536-17-4 | Product Number: V0175
Vidarabine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-β-D-Arabinofuranosyl-9H-purin-6-amine
- Adenine 9-β-D-Arabinofuranoside
- 6-Amino-9-β-D-arabinofuranosylpurine
- Ara-A
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5G |
¥130.00
|
1 | 1 | 2 |
| 25G |
¥400.00
|
4 | Contact Us | 12 |
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| Product Number | V0175 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3N__5O__4 = 267.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 5536-17-4 |
| Reaxys Registry Number | 624881 |
| PubChem Substance ID | 468593117 |
| MDL Number | MFCD00065471 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation | -2.0 to -4.0 deg(C=1, DMF) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 257 °C |
| Maximum Absorption Wavelength | 260 nm (H__2O) |
GHS
| Signal Word | Warning |
| Hazard Statements | H316 : Causes mild skin irritation. |
| Precautionary Statements | P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | AU6200000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Vidarabine: An Arabinosyladenine with Ant-Virus and Anti-Cancer Activities
Vidarabine (arabinosyladenine, ara-A) is a synthetic purine nucleoside, and was first synthesized by Lee et al. in 1960. Vidarabine was originally intended as an anti-cancer agent, while the anti-viral activity against herpesvirus and vaccinia virus was reported by Rudder et al in 1965. And also the activity against varicella-zoster virus was reported by Miller et al. in 1968. Vidarabine had a broad-spectrum activity against DNA viruses but little activity against RNA viruses. Vidarabine is converted to the active form vidarabine triphosphate (ara-ATP) which inhibits viral DNA polymerase activity in vitro and in vivo. (The product is for research purpose only.)
References
- Potential Anticancer Agents.1 Xl. Synthesis of the β-Anomer of 9-(D-Arabinofuranosyl)-Adenine
- Inhibitory effect of some nucleosides on the growth of various human viruses in tissue culture.
- Antiviral activity of 9-beta-D-arabinofuranosyladenine. I. Cell culture studies.
- Inhibition of Herpesvirus DNA Synthesis by 9-β-D-Arabinofuranosyladenine in Cellular and Cell-Free Systems
- The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA)
- Vidarabine: a preliminary review of its pharmacological properties and therapeutic use
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