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Rearranged During Transfection (RET) Kinase Inhibitors

 RET (Rearranged During Transfection) protein is activated as a receptor tyrosine kinase by interacting with GDNF (Glial Cell Line Derived Neuotrophic Factor), such interaction activates signaling pathways including PI3K-Akt signaling pathway and MAPK signaling pathway. It has been reported that a certain type of mutation in RET, known as ‘rearrangement’, fuse the RET gene with other nearby genes, resulting in a RET protein that contains parts of other proteins which makes it hyperactive oncogene and correlates with development of thyroid gland cancer and lung cancer.
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Product Number R0202
CAS RN 269730-03-2
Purity / Analysis Method: >95.0%(HPLC)

Product Number R0142
CAS RN 755037-03-7
Purity / Analysis Method: >98.0%(HPLC)

Product Number:   R0202 | Purity / Analysis Method:   >95.0%(HPLC)

Product Number:   R0142 | Purity / Analysis Method:   >98.0%(HPLC)