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CAS RN: 117048-59-6 | Product Number: C2520

Combretastatin A4


Purity: >98.0%(HPLC)
Synonyms:
  • (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol
  • 3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene
Documents:
250MG
₹34,700
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Product Number C2520
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__8H__2__0O__5 = 316.35  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive,Heat Sensitive
CAS RN 117048-59-6
Reaxys Registry Number 4786976
PubChem Substance ID 253660156
Merck Index (14) 2494
MDL Number

MFCD03453309

Specifications
Purity(HPLC) min. 98.0 area%
Melting point 81.0 to 85.0 °C
Properties (reference)
Melting Point 83 °C
GHS
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Application
Combretastatin A4: Antimitotic Agent

Combretastatin A4 (CA-4), isolated from the African bush willow (Combretum caffrum), binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. Concequentry, CA-4 shows strong cytotoxicity against a variety of tumor cells. Recently, various CA-4 analogs have been synthesized and evaluated for antitumor activity.

References


PubMed Literature


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