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CAS RN: 163042-96-4 | Product Number: C3601
Chloro-IB-MECA
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Purity: >98.0%(HPLC)
Synonyms:
- Cl-IB-MECA
- 2-Chloro-N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide
Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹5,300.00
|
Contact Us | 27 |
|
| 50MG |
₹13,200.00
|
1 | 38 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3601 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__8ClIN__6O__4 = 544.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | 0-10°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 163042-96-4 |
| Reaxys Registry Number | 7154120 |
| PubChem Substance ID | 468591187 |
| MDL Number | MFCD01861178 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 207.0 to 211.0 °C |
| Elemental analysis(Nitrogen) | 14.70 to 16.20 % |
Properties (reference)
| Melting Point | 209 °C |
GHS
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Application
Cl-IB-MECA: A Selective Antagonist of the Adenosine A3 Receptor
Cl-IB-MECA is a selective antagonist of the adenosine A3 receptor (A3R), which is one of the four subtypes of adenosine receptors (A1R, A2AR, A2BR, and A3R). Cl-IB-MECA is selective for the A3R, displaying 2500 and 1400-fold selectivity over A1R and A2AR, respectively.1) The A3R is the only adenosine subtype to be overexpressed in inflammatory and cancer cells, thus making it a potential target for therapy.2-6) (The product is for research purpose only.)
References
- 1) Adenosine A3 receptors: novel ligands and paradoxical effects
- 2) Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A3 receptor agonists
- 3) Disruption of the A3 adenosine receptor gene in mice and its effect on stimulated inflammatory cells
- 4) Modulation of the A3 adenosine receptor by low agonist concentration induces antitumor and myelostimulatory effects (a review)
- 5) Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering (a review)
- 6) Adenosine A3 receptor activation attenuates lungischemia-reperfusion injury
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