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CAS RN: 138977-28-3 | Product Number: C3923
Capsazepine
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- N-(4-Chlorophenethyl)-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carbothioamide
- N-[2-(4-Chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹9,800.00
|
Contact Us | 4 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3923 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__9H__2__1ClN__2O__2S = 376.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 138977-28-3 |
| Reaxys Registry Number | 7047754 |
| MDL Number | MFCD00153778 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 157.0 to 161.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 159 °C |
| Solubility (soluble in) | Ethanol |
GHS
Related Laws:
| RTECS# | CX7075000 |
Transport Information:
Application
Capsazepine: A Competitive Antagonist of TRPV1
Capsazepine is a synthetic analog of capsaicin [M1149] [M0900] that can act as a competitive antagonist of transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel that can be activated by a variety of exogenous and endogenous physical and chemical stimuli.1-3) Recently, capsazepine has been reported to exhibit pleiotropic anticancer effects as an apoptosis inducer against numerous tumor cell lines.4) (The product is for research purpose only.)
References
- 1) Capsazepine: a competitive antagonist of the sensory neuron excitant capsaicin
- 2) Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurons in culture
- 3) The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
- 4) Pleiotropic pharmacological actions of capsazepine, a synthetic analogue of capsaicin, against various cancers and inflammatory diseases (a review)
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