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CAS RN: 53-85-0 | Product Number: D4292
5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 5,6-Dichlorobenzimidazole Riboside
- 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole
- DRB
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
₹5,700.00
|
1 | 18 |
|
| 1G |
₹19,800.00
|
1 | 16 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D4292 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__2H__1__2Cl__2N__2O__4 = 319.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 53-85-0 |
| Reaxys Registry Number | 39123 |
| PubChem Substance ID | 253660379 |
| MDL Number | MFCD00036785 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 220.0 to 224.0 °C |
| Specific rotation [a]20/D | -66.0 ～ -68.0 deg(C=2, Pyridine) |
Properties (reference)
| Melting Point | 222 °C |
| Specific Rotation | -67° (C=2,Pyridine) |
| Maximum Absorption Wavelength | 296 nm |
GHS
Related Laws:
| RTECS# | DD7310000 |
Transport Information:
Application
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB): A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB) is a selective inhibitor of transcription elongation by RNA polymerase II, and then it inhibits of mRNA synthesis in eukaryotic cells. The inhibition can trigger p53-dependent apotosis of tumor cells. DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat).
References
- 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
- The transcriptional elongation inhibitor 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase
- Inhibition of RNA polymerase II as a trigger for the p53 response
- DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation
- Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB
PubMed Literature
Product Articles
[TCIMAIL No.164] DRB : A Selective Inhibitor of Transcription Elongation by RNA Polymerase IIProduct Documents (Note: Some products will not have analytical charts available.)
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Specifications
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