Maximum quantity allowed is 999
Please select the quantity
CAS RN: 104227-87-4 | Product Number: F0842
Famciclovir
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 500MG |
₹5,700.00
|
1 | 12 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | F0842 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__9N__5O__4 = 321.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 104227-87-4 |
| Reaxys Registry Number | 4208403 |
| PubChem Substance ID | 160871205 |
| MDL Number | MFCD00866964 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 103.0 to 107.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 105 °C |
| Maximum Absorption Wavelength | 310 nm (EtOH) |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Ethanol, Methanol |
GHS
Related Laws:
| RTECS# | TY3164000 |
Transport Information:
Application
Famciclovir: A Prodrug of Penciclovir
Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)
References
- Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
- Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action
- In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver
- Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
- In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
Application
Studies on the Antiviral Activities of Famciclovir
Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)
References
- Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
- Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action
- In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver
- Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
- In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.