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Published TCIMAIL newest issue No.199 | Product Document Searching Made Easy by 2D Code! | [TCIPracticalExample] Ullmann-Type Coupling Reaction Using...
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CAS RN: 107007-99-8 | Product Number: G0401
Granisetron Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
₹3,200.00
|
Contact Us | 6 |
|
| 1G |
₹13,100.00
|
1 | 27 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | G0401 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__4N__4O·HCl = 348.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 107007-99-8 |
| Related CAS RN
|
109889-09-0 |
| Reaxys Registry Number | 3640184 |
| PubChem Substance ID | 172089139 |
| Merck Index (14) | 4536 |
| MDL Number | MFCD01747034 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 292 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NK7882200 |
Transport Information:
Application
Granisetron Hydrochloride: A Potent and Highly Selective 5-Hydroxytryptamine 3 (5-HT3) Receptor Antagonist
Granisetron hydrochloride is a potent and highly selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist that has little or no affinity for other serotonin receptors, including 5-HT1; 5-HT1A; 5-HT1B/C; 5-HT2; for α1-, α2- or β-adrenergic receptors; for dopamine-D2; or for histamine-H1; benzodiazepine; picrotoxin or opioid receptors. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, granisetron is used for the prevention of chemotherapy-induced nausea and vomiting. (The product is for research purpose only.)
References
- Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron)
- 5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives
- [3H]-BRL 43694 (granisetron), a specific ligand for 5-HT3 binding sites in rat brain cortical membranes
- Structural features of the ligand-binding domain of the serotonin 5HT3 receptor
- Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: Are they all the same?(a review)
- Direct plasma liquid chromatographic-tandem mass spectrometric analysis of granisetron and its 7-hydroxy metabolite utilizing internal surface reversed-phase guard columns and automated column switching devices
- Development and application of a validated stability-indicating HPLC method for simultaneous determination of granisetron hydrochloride, benzyl alcohol and their main degradation products in parenteral dosage forms
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