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CAS RN: 870281-82-6 | Product Number: I1005
Idelalisib
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Purity: >98.0%(HPLC)(N)
Synonyms:
- CAL-101
- GS-1101
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
₹12,500.00
|
Contact Us | 22 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | I1005 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__2H__1__8FN__7O = 415.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 870281-82-6 |
| Reaxys Registry Number | 25802168 |
| MDL Number | MFCD19443647 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
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Transport Information:
Application
Idelalisib: A Selective Inhibitor of Phosphatidylinositol-3-Kinase (PI3Kδ)
Idelalisib is a selective inhibitor of phosphatidylinositol-3-kinase (PI3Kδ), which mediates B-cell receptor (BCR) signaling and microenvironmental support signals that promote the growth and survival of malignant B lymphocytes. It has been reported that idelalisib induces apoptosis and inhibits proliferation in cell lines derived from malignant B lymphocytes and in primary tumor cells. Recently, idelalisib has been approved for the treatment of several hematological malignancies. (The product is for research purpose only.)
References
- J. R. Somoza, D. Koditek, A. G. Villaseñor, N. Novikov, M. H. Wong, A. Liclican, W. Xing, L. Lagpacan, R. Wang, B. E. Schultz, G. A. Papalia, D. Samuel, L. Lad, M. E. McGrath, J. Biol. Chem. 2015, 290, 8439.
- C. U. Niemann, A. Wiestner, Semin. Cancer Biol. 2013, 23, 410.
- J. A. Burger, K. Okkenhaug, Nat. Rev. Clin. Oncol. 2014, 11, 184.
- A. Markham, Drugs 2014, 74, 1701.
Documents
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