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CAS RN: 186611-52-9 | Product Number: I1077
IC 261
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Purity: >98.0%(HPLC)
Synonyms:
- 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
- 3-(2,4,6-Trimethoxybenzylidene)indolin-2-one
Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹7,300.00
|
Contact Us | 24 |
|
| 50MG |
₹14,200.00
|
Contact Us | 30 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | I1077 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__7NO__4 = 311.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | 0-10°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 186611-52-9 |
| Reaxys Registry Number | 14433656 |
| PubChem Substance ID | 468592079 |
| MDL Number | MFCD00118156 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 212.0 to 216.0 °C |
Properties (reference)
| Melting Point | 214 °C |
GHS
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Application
IC261: A Specific Inhibitor of Casein Kinase 1 (CK1)
Reportedly, IC261 is a specific inhibitor of the protein kinases casein kinase 1 (CK1).
References
- Crystal structure of a conformation-selective casein kinase-1 inhibitor
- Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo
- IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation
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