Losartan Potassium

Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor, and an important component in the pathophysiology of hypertension. Angiotensin II can activate two different receptors, AT₁ and AT₂. The most important vasoconstrictor action of angiotensin II are mediate trough AT₁ receptors. Losartan [L0378] is a prodrug, and its active metabolite (EXP3174) works as a reversible, non-competitive antagonist of the AT₁ receptor.^1,2) In addition, neither losartan nor its active metabolite inhibits ACE nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. In clinical, its water-soluble potassium salt (DUP 753) is used for the treatment of hypertension. Recently, AT₁ receptor antagonists (blockers), such as losartan, are expected as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections.³⁾ (The product is for research purpose only.)