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CAS RN: 75629-57-1 | Product Number: O0450
Oncrasin 1
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Purity: >95.0%(HPLC)
Synonyms:
- 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
- 1-(4-Chlorobenzyl)-1H-indole-3-carboxaldehyde
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹8,400.00
|
Contact Us | 8 |
|
| 50MG |
₹13,800.00
|
Contact Us | 23 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | O0450 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__2ClNO = 269.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 75629-57-1 |
| Reaxys Registry Number | 5549127 |
| PubChem Substance ID | 253660594 |
| MDL Number | MFCD01051808 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 4.90 to 5.50 % |
| Melting point | 115.0 to 119.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 117 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
RNAポリメラーゼII阻害剤，オンクラシン1
Oncrasin 1 is a RNA polymerase II inhibitor with antitumor activity. Oncrasin 1 analogs have been studied to improve the activity.
References
- 1)Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota
- 2)Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)
- 3)Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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