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CAS RN: 50-55-5 | Product Number: R0007


Purity: >98.0%(T)(HPLC)
4   ≥20 
3   ≥20 

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Product Number R0007
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__3__3H__4__0N__2O__9 = 608.69  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
CAS RN 50-55-5
Reaxys Registry Number 102015
PubChem Substance ID 87575589
SDBS (AIST Spectral DB) 10992
Merck Index (14) 8145
MDL Number


Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D -172 to -182 deg(C=1, DMF)
Properties (reference)
Specific Rotation 177° (C=1,DMF)
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H360 : May damage fertility or the unborn child.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# ZG0350000
Transport Information:
Efflux pump inhibitor

Reserpine can potentially inhibit a diverse range of different efflux pumps, including the resistance nodulation division (RND) family. 1,2)


Reserpine: A Central Nervous System Depressant and an Inhibitor of Multidrug Efflux Pumps in Bacteria

Reserpine is an alkaloid of rauwolfia sharing the yohimbine [Y0002] pentacyclic skeleton. Pharmacological studies have revealed that reserpine is a central nervous system depressant. Reserpine depletes stores of catecholamines (dopamine [A0305], noradrenaline [A0906] and adrenaline [A0173]) and 5-hydroxytryptamine [S0370] by inhibiting their accumulation in many organs, including the brain and adrenal medulla. The depression of the central nervous system results in a decreased heart rate and a lowering of arterial blood pressure.
In addition, some studies have reported that reserpine enhances the in vitro activity of fluoroquinolones, such as norfloxacin [N0817], ciprofloxacin [C2227, C2510] and sparfloxacin [S0840], against strains of Staphylococcus aureus expressing distinct efflux-related multidrug resistance pumps. (The product is for research purpose only.)


Reagen for myalgia model


  • Depletion and recovery of neuronal monoamine storage in rats of different ages treated with reserpine
    • F. Ponzio, G. Achilli, G. Calderini, P. Ferretti, C. Perego, G. Toffano, S. Algeri, Neurobiol. Aging. 1984, 5, 101.
  • Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia

Reagent for pain model


Reagent for schizophrenia model


PubMed Literature

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