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CAS RN: 82640-04-8 | Product Number: R0109
Raloxifene Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹13,200.00
|
1 | ≥40 |
|
| 5G |
₹29,900.00
|
3 | 29 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | R0109 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__2__7NO__4S·HCl = 510.05 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 82640-04-8 |
| Related CAS RN | 84449-90-1 |
| Reaxys Registry Number | 6036780 |
| PubChem Substance ID | 172089090 |
| Merck Index (14) | 8098 |
| MDL Number | MFCD01938233 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 263 °C |
| Maximum Absorption Wavelength | 286 nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | PC4956925 |
Transport Information:
Application
Raloxifene Hydrochloride: Selective Estrogen Receptor Modulator (SERM)
Raloxifene hydrochloride is a nonsteroidal estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM). Raloxifene is a therapeutic agent for postmenopausal osteoporosis, and also is indicated for the reduction in risk of invasive breast cancer in postmenopausal women. The biological actions are mediated through binding to estrogen receptors in the cell nucleus. This binding results in activation of estrogenic pathways in bone (agonism) and blockade of estrogenic pathways in breast and uterus (antagonism). (The product is for research purpose only.)
References
- Molecular determinants for the tissue specificity of SERMs
- The selective estrogen receptor modulator, raloxifene: An overview of nonclinical pharmacology and reproductive and developmental testing
- Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats
- Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6- hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride (LY 156758), a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity
- Molecular basis of agonism and antagonism in the estrogen receptor
- Tamoxifen, raloxifene, and the prevention of breast cancer
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