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Maximum quantity allowed is 999
CAS RN: 4083-64-1 | Product Number: T0998
- Tosyl Isocyanate
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|Purity / Analysis Method||>95.0%(T)|
|Molecular Formula / Molecular Weight||C__8H__7NO__3S = 197.21|
|Physical State (20 deg.C)||Liquid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Moisture Sensitive|
|Reaxys Registry Number||391287|
|PubChem Substance ID||87576806|
|SDBS (AIST Spectral DB)||13756|
|Appearance||Colorless to Almost colorless clear liquid|
|Purity(Neutralization titration)||min. 95.0 %|
|Melting Point||-2 °C|
|Boiling Point||130 °C/6 mmHg|
|Flash point||145 °C|
|Specific Gravity (20/20)||1.30|
|Solubility (soluble in)||Acetone, Toluene|
|Hazard Statements||H332 : Harmful if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 : May cause respiratory irritation.
|Precautionary Statements||P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P284 : Wear respiratory protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
- p-Toluenesulfonyl isocyanate as a novel derivatization reagent to enhance the electrospray ionization and its application in the determination of two stereo isomers of 3-hydroxyl-7-methyl-norethynodrel in plasma
- Development and validation of an LC?ESI/MS/MS method with precolumn derivatization for the determination of betulin in rat plasma
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
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