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CAS RN: 2567792-04-3 | Product Number: U0150
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|Purity / Analysis Method||>98.0%(GC)|
|Molecular Formula / Molecular Weight||C__4H__9NO__2S = 135.18|
|Physical State (20 deg.C)||Liquid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Air Sensitive|
|Reaxys Registry Number||37039374|
|PubChem Substance ID||468593100|
|Appearance||Colorless to Light yellow clear liquid|
|Purity(GC)||min. 98.0 %|
|Boiling Point||75 °C/30 mmHg|
|Flash point||27 °C|
|Specific Gravity (20/20)||1.06|
|Hazard Statements||H226 : Flammable liquid and vapor.
|Precautionary Statements||P501 : Dispose of contents/ container to an approved waste disposal plant.
P240 : Ground/bond container and receiving equipment.
P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P233 : Keep container tightly closed.
P243 : Take precautionary measures against static discharge.
P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 : Use only non-sparking tools.
P280 : Wear protective gloves/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P403 + P235 : Store in a well-ventilated place. Keep cool.
To a solution of tBuONSO (400 mg, 2.96 mmol), in THF (anhydrous, 12 mL) was added p-tolylmagnesium bromide (19% in tetrahydrofuran, ca. 1mol/L, 4.4 mL, 4.4 mmol) at -78 °C and the mixture was stirred at -78 °C for 1 hour. The suspension was warmed at room temperature and stirred for overnight. After that, methanol (1 mL) was add to the reaction mixture and the solvent was removed under reduced pressure. The residue was purified by column chromatography (ethyl acetate:hexane = 0:1 - 1:4 on silica gel) to give 4-methylbenzenesulfonamide as a white solid (407 mg, 80%).
The reaction mixture was monitored by UPLC.
1H NMR (400 MHz, CDCl3); δ 7.70 (d, 2H, J = 8.4 Hz), 7.36 (d, 2H, J = 8.1 Hz), 7.27 (brs, 2H), 2.33 (s, 3H).
- Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N‑Sulfinyl‑O‑(tert-butyl)hydroxylamine, t‑BuONSO
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