It has come to our notice that certain fraudulent individuals or entities are misusing our Company’s name and TCI’s registered trademarks by promoting and offering regulated and hazardous chemical substances through online platforms like YouTube. We hereby categorically clarify that TCI has no association or connection whatsoever with the products being displayed or sold in the videos. These products have been falsely represented as being associated with TCI, and the unauthorized use of our trademark and brand name is both illegal and misleading. TCI Chemicals markets and sells its products exclusively through its official website and authorized distributors. If you become aware of any such fraudulent activity or require clarification, you may reach out to us at: Sales-IN@TCIchemicals.com. Click Here to View the Caution Notice.
Product Document Searching Made Easy by 2D Code! | [Product Highlights] Endogenous Biotin-Blocking Reagent...Maximum quantity allowed is 999
Azetidine-Containing Tertiary Boronic Acid Esters
Azetidine-containing tertiary boronic esters (1-4) are useful building blocks for drug discovery researches. Incorporation of azetidine moieties into drug candidates enables improvement of metabolic stability by decreasing lipophilicity and introducing more three-dimensional substructures required by recent trends of drug design.1)
In addition, the pinacol borane moiety can be further converted into a variety of functionalized groups.2) For example, oxidation (a), olefination (b), conversion into trifluoroborate salts (c), an aromatic substitution reaction like the Minisci reaction (d) and visible light photoredox reaction (e) can be applied. Therefore, 1-4 are also good precursors of unique azetidine derivatives.
References
- 1) Multifaceted Substrate-Ligand Interactions Promote the Copper-Catalyzed Hydroboration of Benzylidenecyclobutanes and Related Compounds
- 2) Stereospecific functionalizations and transformations of secondary and tertiary boronic esters
Related Compounds
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.