Turmeric containing curcumin, a yellow dye, has been used as
a South Asian traditional medicine for hepatobiliary disorders, inflammation, and wound healing. Curcumin has
anti-proliferative, cancer-chemopreventive, anti-angiogenic, and anti-oxidant effects. However, its low
bioavailability causes limitations of its application to chemotherapy.
GO-Y030 and GO-Y078 are synthetic analogs of curcumin, develoa hped by
Shibata, Iwabuchi et al. to increase the antitumor potential and improve the bioavailability.2,3)
The assays on various cancer cell lines revealed that GO-Y030 and GO-Y078 suppress tumor cell growth and
control the growth-related molecules such as NF-κB, β-catenin, STAT3, c-Myc and
IRF-4.4,5) It has been reported that they inhibit in vivo cancer cell growth in a mouse model of
gastric cancer
and GO-Y078 having a twice higher water-solubility than curcumin is even more effective.5)
Maximum quantity allowed is 999
Please select the quantity
Curcumin Analogs with Enhanced Antitumor Activities
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References
- 1) Review: H. Shibata, Y. Iwabuchi, in Curcumin: Biosynthesis, Medicinal Uses and Health Benefits, ed. by J. Sasaki, M. Kichida, Nova Science Publishers, New York, 2012, Chap. 7, pp. 177-192.
- 2) H. Ohori, H. Yamakoshi, M. Tomizawa,
M. Shibuya, Y. Kakudo, A. Takahashi, S. Takahashi, S. Kato, T. Suzuki, C. Ishioka, Y. Iwabuchi, H. Shibata, Mol.
Cancer Ther. 2006, 5, 2563.
- 3) H. Yamakoshi, H. Ohori, C. Kudo, A. Sato,
N. Kanoh, C. Ishioka, H. Shibata, Y. Iwabuchi, Bioorg. Med. Chem. 2010, 18, 1083.
- 4) C. Kudo, H. Yamakoshi, A. Sato, H. Ohori, C. Ishioka, Y. Iwabuchi, H. Shibata, Anticancer Res. 2011, 31, 3719.
- 5) C. Kudo, H. Yamakoshi, A. Sato, H. Nanjo, H.
Ohori, C. Ishioka, Y. Iwabuchi, H. Shibata, BMC Pharmacol. 2011, 11, 4.