Sign up for free shipping on all website orders, no minimum required, and get exclusive coupons!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 627810-06-4 | Product Number: B6654
BMVC
×
![]()
×
Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 3,6-Bis[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-9H-carbazole Diiodide
- 4,4′-(9H-Carbazole-3,6-diyldi-2,1-ethenediyl)bis(1-methylpyridinium) Diiodide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 5MG |
$227.00
|
Ships from Portland the same day* | 1 | ≥100 |
|
|
| 25MG |
$681.00
|
Ships from Portland the same day* | 1 | ≥100 |
|
* Items in stock locally typically ship the same day of ordering. Items from Japan stock are able to ship from a US warehouse within 2 weeks after ordering. For additional estimated shipment times, please refer to the Shipping Simulation tool. Note: Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B6654 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__8H__2__5I__2N__3 = 657.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 627810-06-4 |
| Reaxys Registry Number | 21918735 |
| MDL Number | MFCD32671332 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2933.39.6191 |
Application
BMVC: A Fluorescent G4 Ligand with Telomerase Inhibitory Activity
Guanine quadruplexes (G4s) are non-Watson-Crick four-stranded nucleic acid structures held together by noncanonical G-G base tetrads. Recent studies indicate their existence in vivo and their involvement in various biological processes.1) BMVC, a fluorescent G4 ligand, can be used not only as a fluorescent probe to image endogenous and exogenous G4 in living cells,2,3) but also as a reagent to arrest cancer growth by inhibiting telomerase activity and regulating gene expression.3-5) Thus, BMVC is an invaluable reagent for detecting G4 in cells, investigating the biological function of G4, and guiding the development of anti-cancer agents.5,6) (The product is for research use only.)
References
- 1) G-quadruplex interacting small molecules and drugs: from bench toward bedside (a review)
- 2) Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative
- 3) A novel carbazole derivative, BMVC: A potential antitumor agent and fluorescence marker of cancer cells
- 4) G-Quadruplex Stabilizer 3,6-Bis(1-Methyl-4-Vinylpyridinium)Carbazole Diiodide Induces Accelerated Senescence and Inhibits Tumorigenic Properties in Cancer Cells
- 5) Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents
- 6) A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth (a review)
Documents
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.