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CAS RN: 30516-87-1 | 產品號碼: A2052
3'-Azido-3'-deoxythymidine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | A2052 |
純度/分析方法 
|
>98.0%(T) |
| 分子式 / 分子量 | C__1__0H__1__3N__5O__4 = 267.25 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 30516-87-1 |
| Reaxys-RN | 3595791 |
| PubChem Substance ID | 87559740 |
| SDBS (AIST Spectral DB) | 51948 |
| Merck Index(14) | 10123 |
| MDL編號 | MFCD00006536 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 122.0 to 126.0 °C |
| Specific rotation [a]20/D | +43.0 to +51.0 deg(C=1, H2O) |
| NMR | confirm to structure |
性質
| 熔點 | 124 °C |
| 比旋光 [α]D | 47° (C=1,H2O) |
| 水溶性 | Slightly soluble |
| Degree of solubility in water | 20 g/l 25 °C |
| 溶解性（可溶於） | Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H351 : Suspected of causing cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | XP2072000 |
運輸資料
| HS編碼* | 2940.00-000 |
Application
CRISPR Genome Editing / Research on regenerative medicine
Reference
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Application
ortho-Selective C-H Silylation of Aryl Compounds Using an Iridium Catalyst
References
- Clicking 3'-Azidothymidine into Novel Potent Inhibitors of Human Immunodeficiency Virus
Application
A Synthetic Building Block of Rilpivirine
References
- Synthesis and Antitumor Activities of Novel 1,2,3-Triazole-fused Oligoconjugates Based on Nucleoside and Saccharide
Application
Zidovudine (AZT): a Nucleotide Reverse Transcriptase Inhibitor (NRTI)
3'-Azido-2',3'-dideoxythymidine (AZT, Zidovudine) is a nucleotide reverse transcriptase inhibitor (NRTI). It shows activity against human immunodeficiency virus (HIV). In 1985, AZT was found to inhibit the HIV in vitro (Mitsuya et al.). AZT, after conversion to AZT-5'-triphosphate (AZT-TP) by cellular enzymes, inhibits HIV-reverse transcriptase (HIV-RT).
References
- 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
- Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
- AIDS-driven nucleoside chemistry.
- The bottleneck in AZT activation
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
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