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CAS RN: 2353-33-5 | 產品號碼: A2232
5-Aza-2'-deoxycytidine
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| 產品號碼 | A2232 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__8H__1__2N__4O__4 = 228.21 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 2353-33-5 |
| Reaxys-RN | 617982 |
| PubChem Substance ID | 160871263 |
| Merck Index(14) | 2853 |
| MDL編號 | MFCD00043011 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 191 °C(dec.) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H341 : Suspected of causing genetic defects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | XZ3012000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
An Inhibitor of DNA Methylation
The cytidine analogs 5-aza-2'-deoxycytidine and 5-azacytidine [A2033] are inhibitors of DNA methyltransferases (DNMTs) which catalyze the transfer of a methyl group to DNA. DNA methylation is an epigenetic factor and plays an important role in regulating gene expression. 5-Azacytidine and 5-aza-2'-deoxycytidine are the currently most advanced agents for epigenetic cancer therapies. (The product is for research purpose only.)
References
- 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy
- Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
- Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines
- Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-Aza-2'-deoxycytidine
- Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method
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