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CAS RN: 69655-05-6 | 產品號碼: D3066
2',3'-Dideoxyinosine
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補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | D3066 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__0H__1__2N__4O__3 = 236.23 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 500MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 69655-05-6 |
| Reaxys-RN | 3619529 |
| PubChem Substance ID | 87559876 |
| SDBS (AIST Spectral DB) | 52174 |
| Merck Index(14) | 3098 |
| MDL編號 | MFCD00077728 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -26.0 to -30.0 deg(C=0.34, H2O) |
| NMR | confirm to structure |
性質
| 熔點 | 182 °C |
| 比旋光 [α]D | -28° (C=0.34,H2O) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | NM7460700 |
運輸資料
| HS編碼* | 2940.00-000 |
Application
Didanosine (ddI): A Nucleoside Reverse Transcriptase Inhibitor
2',3'-Dideoxyadenosine (ddA) [D3065] and didanosine (ddI) are nucleoside reverse transcriptase inhibitors. ddA is a synthetic nucleoside analogue of the naturally occurring nucleoside 2’-deoxyadenosine in which the 3'-hydroxyl group is replaced by hydrogen. Intracellularly, ddA and ddI are converted by cellular enzymes to the active metabolite, ddA- 5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxyadenosine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Didanosine. A review of its antiviral activity, pharmacokinetic properties and therapeutic potential in human immunodeficiency virus infection.
- Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease
- Didanosine: an updated review of its use in HIV infection
- Didanosine enteric-coated capsule: current role in patients with HIV-1 infection
- Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?
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