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CAS RN: 69123-98-4 | 產品號碼: D4200
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | D4200 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__9H__1__0FIN__2O__5 = 372.09 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 69123-98-4 |
| Reaxys-RN | 892318 |
| PubChem Substance ID | 160871154 |
| Merck Index(14) | 4069 |
| MDL編號 | MFCD00866922 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
性質
| 熔點 | 226 °C |
GHS
相關法規
| RTECS # | YQ9512500 |
運輸資料
| HS編碼* | 2940.00-000 |
Application
Fialuridine (FIAU): A Thymidine Nucleoside Analog with Activity against Herpes Viruses and Hepatitis B Virus (HBV)
Fialuridine (FIAU) is a thymidine nucleoside analog with activity against various herpes viruses and hepatitis B virus (HBV). FIAU blocks the action of DNA polymerases, thus inhibiting viral replication. FIAU owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. On the other hand, it appear that FIAU causes mitochondrial toxicity leading to fatal liver failure alongside lactic acidosis. (The product is for research purpose only.)
References
- Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analog for chronic hepatitis B
- Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
- Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection
- Review article: Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU)
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