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CAS RN: 7226-77-9 | 產品號碼: D4220
2'-Deoxy-5-(hydroxymethyl)cytidine
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| 產品號碼 | D4220 |
純度/分析方法 
|
>98.0%(T) |
| 分子式 / 分子量 | C__1__0H__1__5N__3O__5 = 257.25 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
200MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 7226-77-9 |
| Reaxys-RN | 28741 |
| PubChem Substance ID | 253660378 |
| MDL編號 | MFCD09842113 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
性質
| 熔點 | 205 °C |
| Maximum Wavelength | 274 nm (H__2O) |
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
2'-Deoxy-5-(hydroxymethyl)cytidine (5-hmdC): the Sixth Nucleoside of the Genome
2'-Deoxy-5-(hydroxymethyl)cytidine (5-hmdC) and its base 5-hydroxymethylcytosine (5-hmC) were recently discovered as an oxidation product of 2’-deoxy-5-methylcytidine [D3610] in mammalian DNA, particularly in stem cell DNA. The function of 5-hmdC is currently not clear, but it is assumed that in stem cells they might be intermediates of an active demethylation process. The detecting 5-hmdC in a genome has been investigated.
References
- The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA
- 5-Hydroxymethylcytosine, the Sixth Base of the Genome (Minireview)
- 5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations
- Determination of genomic 5-hydroxymethyl-2'-deoxycytidine in human DNA by capillary electrophoresis with laser-induced fluorescence
- Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling
- Deamination, Oxidation, and C–C Bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxycytosine
PubMed Literature
文檔
產品介紹報導
[TCIMAIL No.164] 5-hmdC : The Sixth Nucleoside of the Genome[Product Highlights] The Sixth Nucleoside of the Genome, 5-hmdC
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
