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CAS RN: 10347-81-6 | 產品號碼: M2527
Maprotiline Hydrochloride
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| 產品號碼 | M2527 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__3N·HCl = 313.87 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 10347-81-6 |
| 相關CAS RN
|
10262-69-8 |
| Reaxys-RN | 5463242 |
| PubChem Substance ID | 253661753 |
| Merck Index(14) | 5748 |
| MDL編號 | MFCD00079464 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 240.0 to 244.0 °C |
性質
| 熔點 | 242 °C |
| 溶解性（可溶於） | Methanol |
| 溶解性（微溶於） | Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | KJ4555000 |
運輸資料
| HS編碼* | 2921.49-000 |
Application
Maprotiline: An Inhibitor of Norepinephrine Uptake
Maprotiline, a tetracyclic second-generation antidepressant, exhibits strong inhibitory effects on norepinephrine uptake but interferes relatively little on serotonin and dopamine reuptake. Maprotiline is metabolized by polymorphic CYP2D6 and CYP2Cl9 isoforms in the liver. (The product is for research purpose only.)
References
- Maprotiline: a review of its pharmacological properties and therapeutic efficacy in mental depressive states
- Chemistry, Pharmacology, Pharmacokinetics, Adverse Effects, and Efficacy of the Antidepressant Maprotiline Hydrochloride (a review)
- Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine
- Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine
- Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats
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