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CAS RN: 84-02-6 | 產品號碼: P2368
Prochlorperazine Dimaleate
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| 產品號碼 | P2368 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__4ClN__3S·2C__4H__4O__4 = 606.09 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| CAS RN | 84-02-6 |
| 相關CAS RN
|
58-38-8 |
| Reaxys-RN | 3861788 |
| PubChem Substance ID | 354335064 |
| Merck Index(14) | 7761 |
| MDL編號 | MFCD00069330 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
性質
| 熔點 | 194 °C(dec.) |
| Maximum Wavelength | 313 nm (MeOH) |
| 水溶性 | Insoluble |
| 溶解性（不溶於） | Diethyl ether, Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H350 : May cause cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | SO3150000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Prochlorperazine Dimaleate: A Dopamine Receptor Antagonist with Antipsychotic Activity
Prochlorperazine dimaleate is a phenothiazine antipsychotic agent with a piperazine moiety in the side chain. Prochlorperazine possesses strong antiemetic and antipsychotic activity with less sedative action than chlorpromazine [C2481]. The precise mechanism of actions is not fully understood. However, prochlorperazine works as a dopamine and α-adrenergic receptors antagonist, and the functions may be related to the therapeutic effect in psychotic conditions. In addition, there is good evidence to suggest that, in common with other phenothiazine agents, prochlorperazine has antibacterial activity. (The product is for research purpose only.)
References
- Prochlorperazine ― A Review of the Literature since 1956
- Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine
- Simultaneous quantitation of plasma doxorubicin and prochlorperazine content by high-performance liquid chromatography
考研文獻
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