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CAS RN: 36791-04-5 | 產品號碼: R0077
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -33.0 to -37.0 deg(C=1, H2O) |
性質
| 比旋光 [α]D | -36° (C=1,H2O) |
| 水溶性 | Soluble |
| Degree of solubility in water | 142 g/l 25 °C |
| 溶解性（微溶於） | Alcohol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H360 : May damage fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | XZ4250000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Ribavirin: A Ribonucleoside Analog with Antiviral Activity
Ribavirin, a ribonucleoside analog, shows antiviral activity against a variety of viruses both in vitro and in vivo. Although its mechanism of action remains unknown exactly, five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin. These include both direct mechanisms (interference with RNA capping, RNA polymerase inhibition, lethal mutagenesis) and indirect mechanisms (inosine monophosphate dehydrogenase inhibition, immunomodulatory effects). Ribavirin is widely used in combination with interferon-α (IFN-α) to treat hepatitis C virus infection. The addition of ribavirin greatly improves IFN-α responses. (The product is for research purpose only.)
References
- The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
- RNA virus error catastrophe: direct molecular test by using ribavirin
- Mechanism of action of ribavirin in the combination treatment of chronic HCV infection (a review)
- Mechanism of action of interferon and ribavirin in treatment of hepatitis C (a review)
- Mechanisms of action of ribavirin against distinct viruses
- The metabolism, pharmacokinetics and mechanisms of antiviral activity of Ribavirin against hepatitis C virus (a review)
考研文獻
文檔
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