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CAS RN: 171596-29-5 | 產品號碼: T4029
| 產品號碼 | T4029 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__2H__1__9N__3O__4 = 389.41 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 171596-29-5 |
| Reaxys-RN | 9589181 |
| MDL編號 | MFCD07771966 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Specific rotation | +70.0 to +76.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
性質
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Dimethylformamide |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | UQ4431050 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Tadalafil: A cGMP-Specific PDE5 Inhibitor
Tadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) which is the predominant PDE isoenzyme in human corpora cavernosa, as with sildenafil [S0986, Citrate].1,2) Although its chemical structure is significantly different from sildenafil, tadalafil shows significant potency for PDE5 inhibition. Current data suggest that PDE5 modulates distinct regulatory pathways in the cell. This property therefore offer the opportunity for selectively targeting specific PDE5 for treatment of specific disease states.2) In fact, tadalafil is widely used also for the treatment of pulmonary arterial hypertension (PAH) which is a progressive disease that ultimately causes right heart failure and death.3) In addition, tadalafil has been reported in some cases to be contained in adulterated food supplements, and methods for its detection are being developed.4,5) (The product is for research purpose only.)
References
- 1) Tadalafil (a review)
- 2) cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action
- 3) Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension
- 4) Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV
- 5) Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks (a review)
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