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CAS RN: 69655-05-6 | Product Number: D3066

2',3'-Dideoxyinosine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • ddI
  • 9-(2,3-Dideoxy-β-D-ribofuranosyl)-6-oxopurine
  • Didanosine
  • 9-(2,3-Dideoxy-β-D-ribofuranosyl)hypoxanthine
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100MG
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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number D3066
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__2N__4O__3 = 236.23  
Physical State (20 deg.C) Solid
CAS RN 69655-05-6
Reaxys Registry Number 3619529
PubChem Substance ID 87559876
SDBS (AIST Spectral DB) 52174
Merck Index (14) 3098
MDL Number

MFCD00077728

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D -26.0 to -30.0 deg(C=0.34, H2O)
Properties (reference)
Melting Point 182 °C
Specific Rotation -28° (C=0.34,H2O)
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H373 : May cause damage to organs through prolonged or repeated exposure.
H341 : Suspected of causing genetic defects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# NM7460700
Transport Information:
HS Number 2934.99.4400
Application
Didanosine (ddI): A Nucleoside Reverse Transcriptase Inhibitor

2',3'-Dideoxyadenosine (ddA) [D3065] and didanosine (ddI) are nucleoside reverse transcriptase inhibitors. ddA is a synthetic nucleoside analogue of the naturally occurring nucleoside 2’-deoxyadenosine in which the 3'-hydroxyl group is replaced by hydrogen. Intracellularly, ddA and ddI are converted by cellular enzymes to the active metabolite, ddA- 5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxyadenosine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)

References


PubMed Literature


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